Author's response to reviews Title: FRAX (R) tool, the WHO algorithm to predict osteoporotic fractures: an analysis of its discriminative and predictive ability in a Spanish female cohort (FRIDEX). Authors:
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چکیده
Conclusions, page 4. Conclusions FRAX without BMD for major and hip fracture demonstrates a good discriminative capacity with the AUC ROC for Spanish women but its predictive capacity does not adjust well with the current algorithm leading to under diagnosis for major fracture and hip fractures. Simple models based on age or BMD alone predicted 10-year risk of major and hip osteoporotic fractures, as well as more complex FRAX models.
منابع مشابه
FRAX® tool, the WHO algorithm to predict osteoporotic fractures: the first analysis of its discriminative and predictive ability in the Spanish FRIDEX cohort
BACKGROUND The WHO has recently published the FRAX® tool to determine the absolute risk of osteoporotic fracture at 10 years. This tool has not yet been validated in Spain. METHODS/DESIGN A prospective observational study was undertaken in women in the FRIDEX cohort (Barcelona) not receiving bone active drugs at baseline. Baseline measurements: known risk factors including those of FRAX® and ...
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BACKGROUND The FRAX® tool estimates the risk of a fragility fracture among the population and many countries have been evaluating its performance among their populations since its creation in 2007. The purpose of this study is to update the first FRIDEX cohort analysis comparing FRAX with the bone mineral density (BMD) model, and its predictive abilities. METHODS The discriminatory ability of...
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BACKGROUND AND OBJECTIVE To detect FRAX(®) threshold levels that identify groups of the population that are at high/low risk of osteoporotic fracture in the Spanish female population using a cost-effective assessment. PATIENTS AND METHODS This is a cohort study. Eight hundred and sixteen women 40-90 years old selected from the FRIDEX cohort with densitometry and risk factors for fracture at b...
متن کاملPrediction of absolute risk of fragility fracture at 10 years in a Spanish population: validation of the WHO FRAX ™ tool in Spain
BACKGROUND Age-related bone loss is asymptomatic, and the morbidity of osteoporosis is secondary to the fractures that occur. Common sites of fracture include the spine, hip, forearm and proximal humerus. Fractures at the hip incur the greatest morbidity and mortality and give rise to the highest direct costs for health services. Their incidence increases exponentially with age.Independently ch...
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BACKGROUND A Moroccan model for the FRAX tool to determine the absolute risk of osteoporotic fracture at 10 years has been established recently. The study aimed to assess the discriminative capacity of FRAX in identifying women with prevalent asymptomatic vertebral fractures (VFs). METHODS We enrolled in this cross-sectional study 908 post-menopausal women with a mean age of 60.9 years ± 7.7 ...
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